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BFH772

Chemical Structure : BFH772

CAS No.: 890128-81-1

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BFH772 (BFH-772)

Catalog No.: PC-42146Not For Human Use, Lab Use Only.

BFH772 is a potent, selective and orally active VEGFR2 tyrosine kinase inhibitor with IC50 of 3 nM.

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10 mg $118 In stock
25 mg $198 In stock
50 mg $328 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

BFH772 is a potent, selective and orally active VEGFR2 tyrosine kinase inhibitor with IC50 of 3 nM.
BFH772 shows 40-fold less potent activity B-RAF, RET and TIE-2, and >500-fold for FLK-1, FLT-1 and FLT-4.
BFH772 inhibits ligand-induced autophosphorylation of RET, PDGFR and KIT with IC50 of 30-160 nM.
BFH772 potently inhibits VEGF-driven angiogenesis in a chamber model and rodent tumor models at daily doses of less than 3 mg/kg.

Physicochemical Properties

M.Wt 439.3867
Formula C23H16F3N3O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: 7.75 mg/mL
Chemical Name/SMILES

1-Naphthalenecarboxamide, 6-[[6-(hydroxymethyl)-4-pyrimidinyl]oxy]-N-[3-(trifluoromethyl)phenyl]-

References

1. Bold G, et al. J Med Chem. 2016 Jan 14;59(1):132-46.

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