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Chemical Structure : Vatalanib dihydrochloride
CAS No.: 212141-51-0
Catalog No.: PC-42834Not For Human Use, Lab Use Only.
Vatalanib (PTK787) dihydrochloride is a potent, orally available class III receptor tyrosine kinases inhibitor with IC50 of <1 uM for VEGFR, Flt-1, KDR and PDGFRβ.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 50 mg | $98 | In stock | |
| 100 mg | $148 | In stock | |
| 250 mg | $258 | In stock | |
| 1 g | Get quote |
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Vatalanib (PTK787) dihydrochloride is a potent, orally available class III receptor tyrosine kinases inhibitor with IC50 of <1 uM for VEGFR, Flt-1, KDR and PDGFRβ.
Vatalanib (PTK787) shows no activity against EGFR, FGFR-1, c-Met, and Tie-2, or c-Src, c-Abl, and PKC-α.
Vatalanib (PTK787) blocks the VEGF-induced receptor autophosphorylation in CHO cells ectopically expressing the KDR receptor with IC50 of 34 nM.
Vatalanib (PTK787) inhibits EGF and PDGF-induced angiogenesis in a growth factor implant model (25-100 mg/kg).
| M.Wt | 419.7348 | |
| Formula | C20H17Cl3N4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
1-Phthalazinamine, N-(4-chlorophenyl)-4-(4-pyridinylmethyl)-, hydrochloride (1:2) |
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1. Bold G, et al. J Med Chem. 2000 Jun 15;43(12):2310-23.
2. Wood JM, et al. Cancer Res. 2000 Apr 15;60(8):2178-89.
3. Drevs J, et al. Cancer Res. 2000 Sep 1;60(17):4819-24.
4. Hess C, et al. Br J Cancer. 2001 Dec 14;85(12):2010-6.
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