Pazopanib hydrochloride | VEGFR inhibitor

Chemical Structure : Pazopanib hydrochloride

CAS No.: 635702-64-6

Pazopanib hydrochloride (GW786034 hydrochloride)

Catalog No.: PC-42824Not For Human Use, Lab Use Only.

Pazopanib (GW786034) hydrochloride is a potent, orally available, pan-VEGFR inhibitor with IC50 of 10, 30, and 47 nM for VEGFR-1, -2, and -3, respectively.

Packing	Price	Stock
50 mg	$78	In stock
100 mg	$118	In stock
250 mg	$198	In stock
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Biological Activity

Pazopanib (GW786034) hydrochloride is a potent, orally available, pan-VEGFR inhibitor with IC50 of 10, 30, and 47 nM for VEGFR-1, -2, and -3, respectively.
Pazopanib also shows significant activity against the closely related RTKs PDGFRβ, c-Kit, FGFR1, and c-Fms with IC50 of 84, 74, 140, and 146 nM, respectively.
Pazopanib potently inhibits VEGF-induced phosphorylation of VEGFR-2 in HUVEC cells with IC50 of 8 nM.
Pazopanib inhibits in vivo tumor growth, increases MM cell apoptosis, decreases angiogenesis, and prolongs host survival in a xenograft model of human MM.

Physicochemical Properties

M.Wt	473.979
Formula	C21H24ClN7O2S
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	DMSO: 6.4 mg/mL (Need warming)
Chemical Name/SMILES	Benzenesulfonamide, 5-[[4-[(2,3-dimethyl-2H-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methyl-, hydrochloride (1:1)

References

1. Podar K, et al. Proc Natl Acad Sci U S A. 2006 Dec 19;103(51):19478-83.

2. Kumar R, et al. Mol Cancer Ther. 2007 Jul;6(7):2012-21.

3. Harris PA, et al. J Med Chem. 2008 Aug 14;51(15):4632-40.

4. Hurwitz HI, et al. Clin Cancer Res. 2009 Jun 15;15(12):4220-7.

Pazopanib hydrochloride (GW786034 hydrochloride)

Biological Activity

Physicochemical Properties

References

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