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Chemical Structure : Pazopanib hydrochloride
CAS No.: 635702-64-6
Catalog No.: PC-42824Not For Human Use, Lab Use Only.
Pazopanib (GW786034) hydrochloride is a potent, orally available, pan-VEGFR inhibitor with IC50 of 10, 30, and 47 nM for VEGFR-1, -2, and -3, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 50 mg | $78 | In stock | |
| 100 mg | $118 | In stock | |
| 250 mg | $198 | In stock | |
| 1 g | Get quote |
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Pazopanib (GW786034) hydrochloride is a potent, orally available, pan-VEGFR inhibitor with IC50 of 10, 30, and 47 nM for VEGFR-1, -2, and -3, respectively.
Pazopanib also shows significant activity against the closely related RTKs PDGFRβ, c-Kit, FGFR1, and c-Fms with IC50 of 84, 74, 140, and 146 nM, respectively.
Pazopanib potently inhibits VEGF-induced phosphorylation of VEGFR-2 in HUVEC cells with IC50 of 8 nM.
Pazopanib inhibits in vivo tumor growth, increases MM cell apoptosis, decreases angiogenesis, and prolongs host survival in a xenograft model of human MM.
| M.Wt | 473.979 | |
| Formula | C21H24ClN7O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: 6.4 mg/mL (Need warming) |
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| Chemical Name/SMILES |
Benzenesulfonamide, 5-[[4-[(2,3-dimethyl-2H-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methyl-, hydrochloride (1:1) |
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1. Podar K, et al. Proc Natl Acad Sci U S A. 2006 Dec 19;103(51):19478-83.
2. Kumar R, et al. Mol Cancer Ther. 2007 Jul;6(7):2012-21.
3. Harris PA, et al. J Med Chem. 2008 Aug 14;51(15):4632-40.
4. Hurwitz HI, et al. Clin Cancer Res. 2009 Jun 15;15(12):4220-7.
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