Semaxinib (SU5416) | VEGFR2 inhibitor Probechem Biochemicals

Chemical Structure : Semaxinib (SU5416)

CAS No.: 204005-46-9

Semaxinib (SU5416) (SU-5416, SU 5416)

Catalog No.: PC-42557Not For Human Use, Lab Use Only.

Semaxinib (SU5416) is a potent and specific VEGFR2 (KDR/Flk-1) inhibitor with IC50 of 1.04 uM.

Packing	Price	Stock
10 mg	$78	In stock
25 mg	$128	In stock
50 mg	$198	In stock
100 mg	$298	In stock
250 mg		Get quote

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Biological Activity

Semaxinib (SU5416) is a potent and specific VEGFR2 (KDR/Flk-1) inhibitor with IC50 of 1.04 uM.
Semaxinib (SU5416) displays no inhibitory activity against EGFR and FGFR.
Semaxinib (SU5416) inhibits autophosphorylation of the Flk-1 receptor with IC50 of 1.23 uM in ELISA assays, inhibits VEGF-driven mitogenesis of HUVECs with IC50 of 0.04 uM.
Semaxinib (SU5416) affects tumor vascular density and vascular leakage in vivo.

Physicochemical Properties

M.Wt	238.2845
Formula	C15H14N2O
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	DMSO: 22.5 mg/mL
Chemical Name/SMILES	2H-Indol-2-one, 3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylene]-1,3-dihydro-

References

1. Fong TA, et al. Cancer Res. 1999 Jan 1;59(1):99-106.

2. Shaheen RM, et al. Cancer Res. 1999 Nov 1;59(21):5412-6.

3. Mendel DB, et al. Anticancer Drug Des. 2000 Feb;15(1):29-41.

4. Mendel DB, et al. Clin Cancer Res. 2000 Dec;6(12):4848-58.

Semaxinib (SU5416) (SU-5416, SU 5416)

Biological Activity

Physicochemical Properties

References

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