Catalog No.: PC-23664Not For Human Use, Lab Use Only.
EG01377 dihydrochloride is a potent and bioavailable inhibitor of the NRP1/VEGF-A interaction (Kd=1.32 uM), selective for NRP1 over the closely related protein NRP2.
EG01377 dihydrochloride is a potent and bioavailable inhibitor of the NRP1/VEGF-A interaction (Kd=1.32 uM), selective for NRP1 over the closely related protein NRP2. EG01377 demonstrates antiangiogenic, antimigratory, and antitumor effects in in vitro assays. EG01377 blocks glioma-conditioned medium-induced increase in TGFβ production in purified Nrp1+, FoxP3+, and CD25+ populations of Tregs from mice.
