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EG00229 free base

Chemical Structure : EG00229 free base

CAS No.: 1018927-63-3

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EG00229 free base (EG 00229, EG-00229)

Catalog No.: PC-35130Not For Human Use, Lab Use Only.

EG00229 is a specific inhibitor of neuropilin-1 (NRP1)/VEGF-A interaction, inhibits the binding of biotinylated VEGFA to NRP1 with IC50 of 8 uM.

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5 mg $128 In stock
10 mg $198 In stock
25 mg $348 In stock
50 mg $558 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

EG00229 is a specific inhibitor of neuropilin-1 (NRP1)/VEGF-A interaction, inhibits the binding of biotinylated VEGFA to NRP1 with IC50 of 8 uM.
EG00229 also demonstrates to have functional effects on cell-migration and VEGF-R2 phosphorylation.

Physicochemical Properties

M.Wt 497.563
Formula C17H19N7O5S3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(S)-2-(3-(benzo[c][1,2,5]thiadiazole-4-sulfonamido)thiophene-2-carboxamido)-5-((diaminomethylene)amino)pentanoic acid

References

1. Powell J, et al. J Med Chem. 2018 May 10;61(9):4135-4154.

2. Jarvis A, et al. J Med Chem. 2010 Mar 11;53(5):2215-26.

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