Adamastat

Chemical Structure : Adamastat

Catalog No.: PC-27371Not For Human Use, Lab Use Only.

Adamastat is a specific small molecule ADAM15 inhibitor, triggers the reduction of bladder cancer cell viability.

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Biological Activity

Adamastat is a specific small molecule ADAM15 inhibitor, triggers the reduction of bladder cancer cell viability.
Adamastat binds to the active site of the ADAM15 metalloproteinase domain with a calculated binding energy of -9.0 kcal/mol.
Adamastat significantly inhibits the viability of UM-UC-9 and UM-UC-6 cells at 10 uM.
Adamastat (100 mg/kg) reduced tumor growth by 83.8% in grafted UM-UC-6 cells subcutaneously in SCID mice.

Physicochemical Properties

M.Wt	435.50
Formula	C23H21N3O4S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	((4'-amino-[1,1'-biphenyl]-4-yl)sulfonyl)-D-tryptophan

References

1. Lorenzatti Hiles G, et al. PLoS One. 2016 Mar 1;11(3):e0150138.

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Adamastat

Biological Activity

Physicochemical Properties

References

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