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Chemical Structure : Adjudin
CAS No.: 252025-52-8
Catalog No.: PC-45593Not For Human Use, Lab Use Only.
Adjudin (AF-2364) is a potent analog of lonidamine known to disrupt germ cell adhesion, a potential candidate for male contraceptive development.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $168 | In stock | |
| 25 mg | $278 | In stock | |
| 100 mg | Get quote |
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Adjudin (AF-2364) is a potent analog of lonidamine known to disrupt germ cell adhesion, a potential candidate for male contraceptive development.
Adjudin (AF-2364) targets actin filament bundles at the apical ES, blocks the expression of PAR6 and 14-3-3 (also known as PAR5).
Adjudin (AF-2364) also induces apoptosis in cancer cells through a Caspase-3-dependent pathway.
Adjudin (AF-2364) inhibited LPS-induced IL-6 release and IL-6, IL-1β, TNF-α expression in BV2 microglial cells.
| M.Wt | 335.188 | |
| Formula | C15H12Cl2N4O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 34 mg/mL |
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| Chemical Name/SMILES |
1H-Indazole-3-carboxylic acid, 1-[(2,4-dichlorophenyl)methyl]-, hydrazide |
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1. Cheng CY, et al. Spermatogenesis. 2011 Oct;1(4):291-297.
2. Xie QR, et al. Biochem Pharmacol. 2013 Feb 1;85(3):345-55.
3. Shao J, et al. J Neuroimmunol. 2013 Jan 15;254(1-2):83-90.
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