Chemical Structure : Afuresertib
CAS No.:
1047644-62-1
Afuresertib
(GSK 2110183, GSK2110183, LAE002)
Catalog No. : PC-44664Not For Human Use, Lab Use Only.
Afuresertib (GSK2110183) is a potent, selective, ATP-competitive pan-AKT inhibitor with biochemical IC50 of 0.08/2/2.6 nM for AKT1/2/3.
Packing Price Stock Quantity 5 mg $98 In stock 0 1 2 3 4 5 10 mg $148 In stock 0 1 2 3 4 5 25 mg $258 In stock 0 1 2 3 4 5 50 mg $398 In stock 0 1 2 3 4 5 100 mg Get quote 0 1 2 3 4 5
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Purity & Documentation Purity:
>98% (HPLC) Select Batch: PC-4466401
Biological Activity
Afuresertib (GSK2110183) is a potent, selective, ATP-competitive pan-AKT inhibitor with biochemical IC50 of 0.08/2/2.6 nM for AKT1/2/3.
Physicochemical Properties
M.Wt
427.3232
Formula
C18H17Cl2FN4OS
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
DMSO: ≥ 40 mg/mL
Chemical Name/SMILES
2-Thiophenecarboxamide, N-[(1S)-2-amino-1-[(3-fluorophenyl)methyl]ethyl]-5-chloro-4-(4-chloro-1-methyl-1H-pyrazol-5-yl)-
References
1. Dumble M, et al. PLoS One.
2. Spencer A, et al. Blood.
3. Arceci RJ, et al. Pediatr Blood Cancer.
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