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Chemical Structure : Afuresertib
CAS No.: 1047644-62-1
Catalog No.: PC-44664Not For Human Use, Lab Use Only.
Afuresertib (GSK2110183) is a potent, selective, ATP-competitive pan-AKT inhibitor with biochemical IC50 of 0.08/2/2.6 nM for AKT1/2/3.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $98 | In stock | |
| 10 mg | $148 | In stock | |
| 25 mg | $258 | In stock | |
| 50 mg | $398 | In stock | |
| 100 mg | Get quote |
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Afuresertib (GSK2110183) is a potent, selective, ATP-competitive pan-AKT inhibitor with biochemical IC50 of 0.08/2/2.6 nM for AKT1/2/3.
Afuresertib (GSK2110183) also inhibits PKA (IC50=1.3 nM) and AKT1 E17K mutant (IC50=0.2 nM), selective over PKC, PKG isoforms and p70S6K.
Afuresertib (GSK2110183) is orally bioactive.
| M.Wt | 427.3232 | |
| Formula | C18H17Cl2FN4OS | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 40 mg/mL |
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| Chemical Name/SMILES |
2-Thiophenecarboxamide, N-[(1S)-2-amino-1-[(3-fluorophenyl)methyl]ethyl]-5-chloro-4-(4-chloro-1-methyl-1H-pyrazol-5-yl)- |
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1. Dumble M, et al. PLoS One. 2014 Jun 30;9(6):e100880.
2. Spencer A, et al. Blood. 2014 Oct 2;124(14):2190-5.
3. Arceci RJ, et al. Pediatr Blood Cancer. 2017 May;64(5).
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