Chemical Structure : Afuresertib hydrochloride
CAS No.:
1047645-82-8
Afuresertib hydrochloride
(GSK 2110183 hydrochloride, GSK2110183 hydrochloride, LAE002 hydrochloride)
Catalog No.: PC-44665Not For Human Use, Lab Use Only.
Afuresertib (GSK2110183) hydrochloride potent, selective, ATP-competitive pan-AKT inhibitor with biochemical IC50 of 0.08/2/2.6 nM for AKT1/2/3.
| Packing | Price | Stock | Quantity |
| 5 mg | $98 | In stock | |
| 10 mg | $148 | In stock | |
| 25 mg | $258 | In stock | |
| 50 mg | $398 | In stock | |
| 100 mg | | Get quote | |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Purity & Documentation Purity:
>98% (HPLC)
Select Batch:
Biological Activity
Afuresertib (GSK2110183) hydrochloride potent, selective, ATP-competitive pan-AKT inhibitor with biochemical IC50 of 0.08/2/2.6 nM for AKT1/2/3.
Afuresertib (GSK2110183) also inhibits PKA (IC50=1.3 nM) and AKT1 E17K mutant (IC50=0.2 nM), selective over PKC, PKG isoforms and p70S6K.
Afuresertib (GSK2110183) is orally bioactive.
Physicochemical Properties
|
M.Wt
|
463.7841
|
|
Formula
|
C18H18Cl3FN4OS
|
|
Appearance
|
Solid
|
|
CAS No.
|
|
|
Storage
|
- Solide Powder
-
-20 °C 12 Months; 4°C 6 Months
|
- In Solvent
-
-80 °C 6 Months; -20°C 6 Months
|
|
Shipping
|
|
|
Solubility
|
DMSO: ≥ 52 mg/mL
|
|
Chemical Name/SMILES
|
2-Thiophenecarboxamide, N-[(1S)-2-amino-1-[(3-fluorophenyl)methyl]ethyl]-5-chloro-4-(4-chloro-1-methyl-1H-pyrazol-5-yl)-, hydrochloride (1:1)
|
References
1. Dumble M, et al. PLoS One. 2014 Jun 30;9(6):e100880.
2. Spencer A, et al. Blood. 2014 Oct 2;124(14):2190-5.
3. Arceci RJ, et al. Pediatr Blood Cancer. 2017 May;64(5).
Contact Us
sales@probechem.com
