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Akt1/2-IN-17

Chemical Structure : Akt1/2-IN-17

CAS No.: 893422-47-4

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Akt1/2-IN-17 (Compound 17)

Catalog No.: PC-45876Not For Human Use, Lab Use Only.

Akt1/2-IN-17 is a potent, selective dual Akt1 and Akt2 inhibitor with IC50 of 3.5 nM and 42 nM, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Akt1/2-IN-17 is a potent, selective dual Akt1 and Akt2 inhibitor with IC50 of 3.5 nM and 42 nM, respectively.
Akt1/2-IN-17 shows selectivity for Akt1/2 over Akt3 (IC50=1900 nM), and highly selective over other members of the AGC family of kinases.
Akt1/2-IN-17 inhibit the growth of A2780 tumors in vivo; shows good physical properties and PK profile.

 

Physicochemical Properties

M.Wt 539.6296
Formula C33H29N7O
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
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Solubility

DMSO: ≥ 35 mg/mL
Chemical Name/SMILES

1,6-Naphthyridin-5(6H)-one, 3-phenyl-2-[4-[[4-[5-(2-pyridinyl)-1H-1,2,4-triazol-3-yl]-1-piperidinyl]methyl]phenyl]-

References

1. Bilodeau MT, et al. Bioorg Med Chem Lett. 2008 Jun 1;18(11):3178-82.

2. Li Y, et al. Bioorg Med Chem Lett. 2009 Feb 1;19(3):834-6.

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