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Chemical Structure : Akt activator SC79
CAS No.: 305834-79-1
Catalog No.: PC-45548Not For Human Use, Lab Use Only.
SC-79 is a unique specific Akt activator, binds to the PH domain of Akt and inhibits Akt membrane translocation, but paradoxically activates Akt in the cytosol.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $88 | In stock | |
| 25 mg | $138 | In stock | |
| 50 mg | $218 | In stock | |
| 100 mg | $358 | In stock | |
| 250 mg | Get quote |
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SC-79 is a unique specific Akt activator, binds to the PH domain of Akt and inhibits Akt membrane translocation, but paradoxically activates Akt in the cytosol.
SC-79 induces the p-Akt (Ser473) expression and significantly increases the expression of Bcl-2 and p-GSK-3β (Ser9), decreases the protein levels of Bax, cytoplasm cytochrome C, and cleaved caspase-3.
SC-79 augments neuronal survival in mouse model for ischemic strok.
| M.Wt | 364.7803 | |
| Formula | C17H17ClN2O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
4H-1-Benzopyran-4-acetic acid, 2-amino-6-chloro-α-cyano-3-(ethoxycarbonyl)-, ethyl ester |
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1. Jo H, et al. Proc Natl Acad Sci U S A. 2012 Jun 26;109(26):10581-6.
2. Zhang D, et al. ACS Chem Neurosci. 2016 Jun 15;7(6):710-8.
3. Hao S, et al. Molecules. 2016 Mar 10;21(3):325.
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