Akt activator SC79 | Akt activator | Probechem Biochemicals

Chemical Structure : Akt activator SC79

CAS No.: 305834-79-1

Akt activator SC79 (SC-79)

Catalog No.: PC-45548Not For Human Use, Lab Use Only.

SC-79 is a unique specific Akt activator, binds to the PH domain of Akt and inhibits Akt membrane translocation, but paradoxically activates Akt in the cytosol.

Packing	Price	Stock
10 mg	$88	In stock
25 mg	$138	In stock
50 mg	$218	In stock
100 mg	$358	In stock
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Biological Activity

SC-79 is a unique specific Akt activator, binds to the PH domain of Akt and inhibits Akt membrane translocation, but paradoxically activates Akt in the cytosol.
SC-79 induces the p-Akt (Ser473) expression and significantly increases the expression of Bcl-2 and p-GSK-3β (Ser9), decreases the protein levels of Bax, cytoplasm cytochrome C, and cleaved caspase-3.
SC-79 augments neuronal survival in mouse model for ischemic strok.

Physicochemical Properties

M.Wt	364.7803
Formula	C17H17ClN2O5
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4H-1-Benzopyran-4-acetic acid, 2-amino-6-chloro-α-cyano-3-(ethoxycarbonyl)-, ethyl ester

References

1. Jo H, et al. Proc Natl Acad Sci U S A. 2012 Jun 26;109(26):10581-6.

2. Zhang D, et al. ACS Chem Neurosci. 2016 Jun 15;7(6):710-8.

3. Hao S, et al. Molecules. 2016 Mar 10;21(3):325.

Akt activator SC79 (SC-79)

Biological Activity

Physicochemical Properties

References

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