Alcedaplin (MZE829) | APOL1 inhibitor | Probechem Biochemicals

Chemical Structure : Alcedaplin

Alcedaplin (MZE829, MZE-829)

Catalog No.: PC-27404Not For Human Use, Lab Use Only.

Alcedaplin (MZE829) is a small molecule inhibitor of apolipoprotein L1 (APOL1) function, blocks APOL1 pore function and ameliorate manifestations of APOL1-mediated kidney disease (AMKD).

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Biological Activity

Alcedaplin (MZE829) is a small molecule inhibitor of apolipoprotein L1 (APOL1) function, blocks APOL1 pore function and ameliorate manifestations of APOL1-mediated kidney disease (AMKD).

Physicochemical Properties

M.Wt	548.99
Formula	C27H28ClF3N4O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Spiro[3H-indole-3,4'-piperidin]-2(1H)-one, 5-chloro-1'-[2-[[1-(cis-3-hydroxy-3-methylcyclobutyl)-7-(trifluoromethyl)-1H-benzimidazol-5-yl]oxy]ethyl]-

References

1. Patent WO2023141432 A2 2023-07-27.

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Alcedaplin (MZE829, MZE-829)

Biological Activity

Physicochemical Properties

References

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