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Alda-1

Chemical Structure : Alda-1

CAS No.: 349438-38-6

Alda-1 (ALDH2 activator Alda-1)

Catalog No.: PC-45563Not For Human Use, Lab Use Only.

Alda-1 is a small-molecule activator of ALDH2, particularly effective activator of ALDH2*2 (EC50= 20 uM, increases the activity of the mutant, ALDH2*2 (11-fold).

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Biological Activity

Alda-1 is a small-molecule activator of ALDH2, particularly effective activator of ALDH2*2 (EC50= 20 uM, increases the activity of the mutant, ALDH2*2 (11-fold).
Alda-1 causes slight inhibition of GTN denitration and did not increase GTN-induced sGC activation in the presence of either variant; no effect on ADH1.

Physicochemical Properties

M.Wt 324.1588
Formula C15H11Cl2NO3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 51 mg/mL

Chemical Name/SMILES

Benzamide, N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichloro-

References

1. Chen CH, et al. Science. 2008 Sep 12;321(5895):1493-5.

2. Beretta M, et al. J Biol Chem. 2010 Jan 8;285(2):943-52.

3. Ning S, et al. Radiat Res. 2012 Jul;178(1):69-74.

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