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Chemical Structure : Almorexant hydrochloride
CAS No.: 913358-93-7
Catalog No.: PC-42705Not For Human Use, Lab Use Only.
A dual Orexin receptor OX1/OX2 antagonist with Ki of 1.3/0.17 nM for hOX1/hOX2 respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $160 | In stock | |
| 50 mg | $552 | In stock | |
| 100 mg | $960 | In stock |
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A dual Orexin receptor OX1/OX2 antagonist with Ki of 1.3/0.17 nM for hOX1/hOX2 respectively; selectively inhibits the functional consequences of OX1 and OX2 receptor activation, such as intracellular Ca2+ mobilization.
Sleep Disorder
Phase 3 Discontinued
| M.Wt | 549.0242 | |
| Formula | C29H32ClF3N2O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 46 mg/mL |
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| Chemical Name/SMILES |
2(1H)-Isoquinolineacetamide, 3,4-dihydro-6,7-dimethoxy-N-methyl-α-phenyl-1-[2-[4-(trifluoromethyl)phenyl]ethyl]-, hydrochloride (1:1), (αR,1S)- |
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1. Malherbe P, et al. Mol Pharmacol. 2009 Sep;76(3):618-31.
2. Malherbe P, et al. Mol Pharmacol. 2010 Jul;78(1):81-93.
3. Li A, et al. J Physiol. 2010 Aug 1;588(Pt 15):2935-44.
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