Chemical Structure : Almorexant hydrochloride
CAS No.:
913358-93-7
Almorexant hydrochloride
(ACT-078573 hydrochloride;ACT 078573 hydrochloride;ACT078573 hydrochloride)
Catalog No. : PC-42705Not For Human Use, Lab Use Only.
A dual Orexin receptor OX1/OX2 antagonist with Ki of 1.3/0.17 nM for hOX1/hOX2 respectively.
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Purity & Documentation Purity:
>98% (HPLC) Select Batch: PC-4270501
Biological Activity
A dual Orexin receptor OX1/OX2 antagonist with Ki of 1.3/0.17 nM for hOX1/hOX2 respectively; selectively inhibits the functional consequences of OX1 and OX2 receptor activation, such as intracellular Ca2+ mobilization.
Sleep Disorder
Phase 3 Discontinued
Physicochemical Properties
M.Wt
549.0242
Formula
C29H32ClF3N2O3
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
DMSO: ≥ 46 mg/mL
Chemical Name/SMILES
2(1H)-Isoquinolineacetamide, 3,4-dihydro-6,7-dimethoxy-N-methyl-α-phenyl-1-[2-[4-(trifluoromethyl)phenyl]ethyl]-, hydrochloride (1:1), (αR,1S)-
References
1. Malherbe P, et al. Mol Pharmacol. 2009 Sep;76(3):618-31.
2. Malherbe P, et al. Mol Pharmacol. 2010 Jul;78(1):81-93.
3. Li A, et al. J Physiol. 2010 Aug 1;588(Pt 15):2935-44.
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