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Alofanib

Chemical Structure : Alofanib

CAS No.: 1612888-66-0

Alofanib (RPT-835;RPT835;RPT 835;ES 000835)

Catalog No.: PC-60557Not For Human Use, Lab Use Only.

Alofanib ((RPT-835, ES 000835) is a potent, selective, allosteric FGFR2 inhibitor that significantly inhibits bFGF-induced proliferation of HUVEC cells with IC50 of 11 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Alofanib ((RPT-835, ES 000835) is a potent, selective, allosteric FGFR2 inhibitor that significantly inhibits bFGF-induced proliferation of HUVEC cells with IC50 of 11 nM.
Alofanib ((RPT-835) suppresses proliferation of SVEC-4-10 cells with IC50 of 58 nM, inhibits growth of FGFR2-expressing SKOV3 cells with GI50 of 0.37 uM.
Alofanib ((RPT-835) inhibits experimental FGF-induced angiogenesis in vivo.

Physicochemical Properties

M.Wt 413.404
Formula C19H15N3O6S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

3-[[[4-Methyl-2-nitro-5-(3-pyridinyl)phenyl]amino]sulfonyl]benzoic acid

References

1. Khochenkov DA, et al. Bull Exp Biol Med. 2015 Nov;160(1):84-7.

2. Tsimafeyeu I, et al. Med Chem. 2016;12(4):303-17.

3. Tsimafeyeu I, et al. Eur J Cancer. 2016 Jul;61:20-8.

4. Tyulyandina A, et al. Invest New Drugs. 2017 Apr;35(2):127-133.

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