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Chemical Structure : Alofanib
CAS No.: 1612888-66-0
Catalog No.: PC-60557Not For Human Use, Lab Use Only.
Alofanib ((RPT-835, ES 000835) is a potent, selective, allosteric FGFR2 inhibitor that significantly inhibits bFGF-induced proliferation of HUVEC cells with IC50 of 11 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $158 | In stock | |
| 25 mg | $268 | In stock | |
| 50 mg | $428 | In stock | |
| 100 mg | $728 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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Alofanib ((RPT-835, ES 000835) is a potent, selective, allosteric FGFR2 inhibitor that significantly inhibits bFGF-induced proliferation of HUVEC cells with IC50 of 11 nM.
Alofanib ((RPT-835) suppresses proliferation of SVEC-4-10 cells with IC50 of 58 nM, inhibits growth of FGFR2-expressing SKOV3 cells with GI50 of 0.37 uM.
Alofanib ((RPT-835) inhibits experimental FGF-induced angiogenesis in vivo.
| M.Wt | 413.404 | |
| Formula | C19H15N3O6S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
3-[[[4-Methyl-2-nitro-5-(3-pyridinyl)phenyl]amino]sulfonyl]benzoic acid |
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1. Khochenkov DA, et al. Bull Exp Biol Med. 2015 Nov;160(1):84-7.
2. Tsimafeyeu I, et al. Med Chem. 2016;12(4):303-17.
3. Tsimafeyeu I, et al. Eur J Cancer. 2016 Jul;61:20-8.
4. Tyulyandina A, et al. Invest New Drugs. 2017 Apr;35(2):127-133.
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