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Chemical Structure : Alrizomadlin
CAS No.: 1818393-16-6
Catalog No.: PC-62260Not For Human Use, Lab Use Only.
Alrizomadlin (APG-115) is a potent and orally active MDM2 inhibitor with Ki <1 nM, potently inhibits SJSA-1 cell growth with IC50 of 60 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $88 | In stock | |
| 10 mg | $138 | In stock | |
| 25 mg | $228 | In stock | |
| 50 mg | $378 | In stock | |
| 100 mg | $588 | In stock | |
| 250 mg | Get quote |
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Alrizomadlin (APG-115) is a potent and orally active MDM2 inhibitor with Ki <1 nM, potently inhibits SJSA-1 cell growth with IC50 of 60 nM.
Alrizomadlin (APG-115) exhibits IC50 values of 38, 18, and 104 nM in the RS4;11 acute leukemia, LNCaP prostate cancer, and HCT116 colon cancer cell lines, respectively.
Alrizomadlin (APG-115) effectively inhibits tumor growth and causes no or minimal weight loss.
| M.Wt | 642.593 | |
| Formula | C34H38Cl2FN3O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
4-((3'R,4'S,5'R)-6''-chloro-4'-(3-chloro-2-fluorophenyl)-1'-ethyl-2''-oxodispiro[cyclohexane-1,2'-pyrrolidine-3',3''-indoline]-5'-carboxamido)bicyclo[2.2.2]octane-1-carboxylic acid |
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1. Aguilar A, et al. J Med Chem. 2017 Apr 13;60(7):2819-2839.
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