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Alrizomadlin

Chemical Structure : Alrizomadlin

CAS No.: 1818393-16-6

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Alrizomadlin (APG-115, APG115, AA115)

Catalog No.: PC-62260Not For Human Use, Lab Use Only.

Alrizomadlin (APG-115) is a potent and orally active MDM2 inhibitor with Ki <1 nM, potently inhibits SJSA-1 cell growth with IC50 of 60 nM.

Packing Price Stock Quantity
5 mg $88 In stock
10 mg $138 In stock
25 mg $228 In stock
50 mg $378 In stock
100 mg $588 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Alrizomadlin (APG-115) is a potent and orally active MDM2 inhibitor with Ki <1 nM, potently inhibits SJSA-1 cell growth with IC50 of 60 nM.
Alrizomadlin (APG-115) exhibits IC50 values of 38, 18, and 104 nM in the RS4;11 acute leukemia, LNCaP prostate cancer, and HCT116 colon cancer cell lines, respectively.
Alrizomadlin (APG-115) effectively inhibits tumor growth and causes no or minimal weight loss.

Physicochemical Properties

M.Wt 642.593
Formula C34H38Cl2FN3O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-((3'R,4'S,5'R)-6''-chloro-4'-(3-chloro-2-fluorophenyl)-1'-ethyl-2''-oxodispiro[cyclohexane-1,2'-pyrrolidine-3',3''-indoline]-5'-carboxamido)bicyclo[2.2.2]octane-1-carboxylic acid

References

1. Aguilar A, et al. J Med Chem. 2017 Apr 13;60(7):2819-2839.

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