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Amcasertib

Chemical Structure : Amcasertib

CAS No.: 1129403-56-0

Amcasertib (BBI-503, BBI503)

Catalog No.: PC-45384Not For Human Use, Lab Use Only.

Amcasertib (BBI503) is a small-molecule inhibitor that inhibits Nanog and other CSC (cancer stem cells) pathways by targeting kinases.

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Biological Activity

Amcasertib (BBI503) is a small-molecule inhibitor that inhibits Nanog and other CSC (cancer stem cells) pathways by targeting kinases.
Amcasertib targets and inhibits one or more pathways involved in cancer stem cell survival, shows potential antineoplastic activity.

Physicochemical Properties

M.Wt 539.691
Formula C31H33N5O2S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 30 mg/mL

Chemical Name/SMILES

1H-Pyrrole-3-carboxamide, N-[2-(diethylamino)ethyl]-5-[[1,2-dihydro-2-oxo-5-(2-phenyl-4-thiazolyl)-3H-indol-3-ylidene]methyl]-2,4-dimethyl-

References

1. Marcucci F, et al. Front Oncol. 2016 May 10;6:115.

2. Iv Santaliz-Ruiz LE, et al. Int J Cancer. 2014 Dec 15;135(12):2741-8.

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