Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : Aminopyridine 2
Catalog No.: PC-35561Not For Human Use, Lab Use Only.
Aminopyridine 2 (MPO inhibitor AP-2) is a novel potent, selective, orally available inhibitor of Myeloperoxidase (MPO), inhibits MPO peroxidase activity in vitro and in human plasma with IC50 of 0.16 and 1.9 uM, respectively.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Aminopyridine 2 (MPO inhibitor AP-2) is a novel potent, selective, orally available inhibitor of Myeloperoxidase (MPO), inhibits MPO peroxidase activity in vitro and in human plasma with IC50 of 0.16 and 1.9 uM, respectively.
Aminopyridine 2 also inhibits eosinophil peroxidase (EPO, IC50=0.29 uM), and shows no apparent activity against other oxidases.
Aminopyridine 2 blockes MPO-dependent vasomotor dysfunction ex vivo in rat aortic rings, also inhibits MPO activity in vivo in a mouse model of peritonitis.
| M.Wt | 321.178 | |
| Formula | C13H13BrN4O | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Marro ML, et al. J Pharmacol Exp Ther. 2018 Aug 3. pii: jpet.118.248435.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
