Catalog No.: PC-35561Not For Human Use, Lab Use Only.
Aminopyridine 2 (MPO inhibitor AP-2) is a novel potent, selective, orally available inhibitor of Myeloperoxidase (MPO), inhibits MPO peroxidase activity in vitro and in human plasma with IC50 of 0.16 and 1.9 uM, respectively.
Aminopyridine 2 (MPO inhibitor AP-2) is a novel potent, selective, orally available inhibitor of Myeloperoxidase (MPO), inhibits MPO peroxidase activity in vitro and in human plasma with IC50 of 0.16 and 1.9 uM, respectively.
Aminopyridine 2 also inhibits eosinophil peroxidase (EPO, IC50=0.29 uM), and shows no apparent activity against other oxidases.
Aminopyridine 2 blockes MPO-dependent vasomotor dysfunction ex vivo in rat aortic rings, also inhibits MPO activity in vivo in a mouse model of peritonitis.
