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Amisulpride

Chemical Structure : Amisulpride

CAS No.: 71675-85-9

Amisulpride (SEP-4199, DAN2163, DAN 2163)

Catalog No.: PC-23210Not For Human Use, Lab Use Only.

Amisulpride (SEP-4199, DAN2163) is an N-methylated analogue of amisulpride, selective dopamine D(2/3)/5-HT(7) inhibitor, binds to the D2 receptor and 5-HT7 receptor with Ki of 1.1 nM and 44 nM respectively, shows potential for treatment of schizophrenia and other psychiatric disorders.

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Biological Activity

Amisulpride (SEP-4199, DAN2163) is an N-methylated analogue of amisulpride, selective dopamine D(2/3)/5-HT(7) inhibitor, binds to the D2 receptor and 5-HT7 receptor with Ki of 1.1 nM and 44 nM respectively, shows potential for treatment of schizophrenia and other psychiatric disorders.

Physicochemical Properties

M.Wt 369.48
Formula C17H27N3O4S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

4-amino-N-((1-ethylpyrrolidin-2-yl)methyl)-5-(ethylsulfonyl)-2-methoxybenzamide

References

1. Biernat L, et al. Psychopharmacology (Berl). 2022 Sep;239(9):3009-3018.

2. Grattan V, et al. ACS Omega. 2019 Aug 15;4(9):14151-14154.

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