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Antitrypanosomal agent 10

Chemical Structure : Antitrypanosomal agent 10

CAS No.:

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Antitrypanosomal agent 10

Catalog No.: PC-21377Not For Human Use, Lab Use Only.

Antitrypanosomal agent 10 is a potent, orally active antitrypanosomal compound, selectively inhibits the growth of parasites T. b. brucei, T. b. gambiense and T. b. rhodesiense with EC50 of 0.54, 0.13 and 1.14 uM, resepctively.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Antitrypanosomal agent 10 is a potent, orally active antitrypanosomal compound, selectively inhibits the growth of parasites T. b. brucei, T. b. gambiense and T. b. rhodesiense with EC50 of 0.54, 0.13 and 1.14 uM, resepctively.
Antitrypanosomal agent 10 has excellent oral bioavailability and (100 mpk) is effective in treating acute infection of Human African Trypanosomiasis (HAT) in mouse models.

Physicochemical Properties

M.Wt 269.28
Formula C10H11N3O4S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(E)-N-[4-(methylamino)-4-oxobut-2-en-1-yl]-5-nitrothiophene-2-carboxamide

References

1. Ajayi O, et al. Eur J Med Chem. 2023 Nov 15;263:115954.

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