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Apcin

Chemical Structure : Apcin

CAS No.: 300815-04-7

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Apcin

Catalog No.: PC-63039Not For Human Use, Lab Use Only.

Apcin is a cell-permeable, small molecule anaphase-promoting complex/cyclosome (APC/C) inhibitor, which binds to Cdc20 and competitively inhibits the ubiquitylation of D-box-containing substrates.

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5 mg $88 In stock
10 mg $128 In stock
25 mg $218 In stock
50 mg $358 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Apcin is a cell-permeable, small molecule anaphase-promoting complex/cyclosome (APC/C) inhibitor, which binds to Cdc20 and competitively inhibits the ubiquitylation of D-box-containing substrates.
Apcin shows enhanced anti-MM activity combined with another APC/C inhibitor proTAME.

Physicochemical Properties

M.Wt 438.65
Formula C13H14Cl3N7O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

[2,2,2-trichloro-1-(2-pyrimidinylamino)ethyl]-carbamic acid, 2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl ester

References

1. Sackton KL, et al. Nature. 2014 Oct 30;514(7524):646-9.

2. de Lange J, et al. Nat Commun. 2015 Oct 1;6:8399.

3. Lub S, et al. Oncotarget. 2016 Jan 26;7(4):4062-76.

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