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Chemical Structure : Apcin
CAS No.: 300815-04-7
Catalog No.: PC-63039Not For Human Use, Lab Use Only.
Apcin is a cell-permeable, small molecule anaphase-promoting complex/cyclosome (APC/C) inhibitor, which binds to Cdc20 and competitively inhibits the ubiquitylation of D-box-containing substrates.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $128 | In stock | |
| 50 mg | $398 | In stock | |
| 100 mg | Get quote |
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Apcin is a cell-permeable, small molecule anaphase-promoting complex/cyclosome (APC/C) inhibitor, which binds to Cdc20 and competitively inhibits the ubiquitylation of D-box-containing substrates.
Apcin shows enhanced anti-MM activity combined with another APC/C inhibitor proTAME.
| M.Wt | 438.65 | |
| Formula | C13H14Cl3N7O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
[2,2,2-trichloro-1-(2-pyrimidinylamino)ethyl]-carbamic acid, 2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl ester |
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1. Sackton KL, et al. Nature. 2014 Oct 30;514(7524):646-9.
2. de Lange J, et al. Nat Commun. 2015 Oct 1;6:8399.
3. Lub S, et al. Oncotarget. 2016 Jan 26;7(4):4062-76.
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