Chemical Structure : Aplaviroc
CAS No.:
461443-59-4
Aplaviroc
(AK-602, GW 873140, ONO-4128, GSK-873140)
Catalog No. : PC-61968Not For Human Use, Lab Use Only.
Aplaviroc (GSK-873140, GW 873140, AK-602, ONO-4128) is a potent, noncompetitive, allosteric antagonist of the CCR5 receptor with pKb of 8.6.
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Purity & Documentation Purity:
>98% (HPLC) Select Batch: PC-6196801
Biological Activity
Aplaviroc (GSK-873140, GW 873140, AK-602, ONO-4128) is a potent, noncompetitive, allosteric antagonist of the CCR5 receptor with pKb of 8.6.
Physicochemical Properties
M.Wt
577.722
Formula
C33H43N3O6
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
4-[4-[[(3R)-1-butyl-3-[(R)-cyclohexyl(hydroxy)methyl]-2,5-dioxo-1,4,9-triazaspiro[5.5]undecan-9-yl]methyl]phenoxy]benzoic acid
References
1. Watson C, et al. Mol Pharmacol.
2. Lalezari J, et al. AIDS.
3. Adkison KK, et al. Antimicrob Agents Chemother.
4. Nakata H, et al. Antimicrob Agents Chemother.
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