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Chemical Structure : Apoptosis Activator 2
CAS No.: 79183-19-0
Catalog No.: PC-45496Not For Human Use, Lab Use Only.
Apoptosis Activator 2 is an apoptosis activator that strongly induces caspase-3 activation, PARP cleavage, and DNA fragmentation, leads to the destruction of cells (Apaf-1 dependent) with IC50 of 4 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $88 | In stock | |
| 25 mg | $148 | In stock | |
| 50 mg | $228 | In stock | |
| 100 mg | Get quote |
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Apoptosis Activator 2 is an apoptosis activator that strongly induces caspase-3 activation, PARP cleavage, and DNA fragmentation, leads to the destruction of cells (Apaf-1 dependent) with IC50 of 4 uM.
Apoptosis Activator 2 promotes the protein-protein association of Apaf-1 into the functional apoptosome.
Apoptosis Activator 2 exert cytostatic and cytotoxic effects on a variety of cancer cell lines while having little or no activity against the normal cell lines tested.
| M.Wt | 306.1435 | |
| Formula | C15H9Cl2NO2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 46 mg/mL |
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| Chemical Name/SMILES |
1H-Indole-2,3-dione, 1-[(3,4-dichlorophenyl)methyl]- |
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1. Nguyen JT, et al. Proc Natl Acad Sci U S A. 2003 Jun 24;100(13):7533-8.
2. Farivar TN, et al. N Am J Med Sci. 2012 Nov;4(11):582-5.
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