| Cat. No. |
Product Name |
Information |
| PC-22708 |
Necrox-7
HMGB1 inhibitor, Necrosis inhibitor
|
NecroX-7 (NecX, NecroX 7) is a small molecule necrosis inhibitor by inhibiting high-mobility group box 1 protein (HMGB1) release. |
| PC-21095 |
EGCG
Anticancer
|
EGCG (Epigallocatechin-3-gallate) is a major polyphenol in green tea, which can inhibit cell proliferation and induce cell apoptosis, inhibits glutamate dehydrogenase 1/2 (GDH1/2, GLUD1/2) activity. |
| PC-20272 |
ANP0903
Apoptosis inducer
|
ANP0903 is an analog of HIV-1 protease inhibitor darunavir, induces cytotoxicity in hepatocellular carcinoma cell lines, triggers apoptosis by enhancing ER stress. |
| PC-47089 |
Tpz-1
PCD inducer
|
Tpz-1 is a unique cytotoxic compound that elicits potent and selective programmed cell death in human blood, breast, colon, and cervical cancer cell lines, interferes with components of signaling pathways and the cytoskeleton that are important to cell shape, internal organization, growth, and division. |
| PC-38741 |
WZY-321
XAF1 inhibitor
|
WZY-321 a small molecule glioma cell apoptosis inducer, binds to XAF1 3-UTR and decreases XAF1 (X-linked inhibitor of apoptosis-associated factor 1) mRNA levels. |
| PC-38723 |
Devimistat
KGDH inhibitor, PDK activator
|
CPI-613 (Devimistat) is an antimitochondrial metabolism agent that specifically induces inactivating phosphorylation of tumor cell PDH via stimulation of PDKs 1 to 4, inhibits KGDH function strongly and rapidly, selectively in tumor cells. |
| PC-73048 |
Leusin-1
ALL G2 phase inhibitor
|
Leusin-1 (Leukemia specific inhibitor 1) is a cell cycle phase specific inhibitor that specifically arrest leukemia cells during G2-phase and triggers an apoptotic cell death (CCRF-CEM IC50= 2.66 uM and TOM1 IC50= 0.877 uM). |
| PC-72413 |
WEHI-7326
Mitotic inhibitor
|
WEHI-7326 (WEHI 7326) is a specific mitotic inhibitor and potential anticancer agent, causes cell cycle arrest in G2/M, cell death in vitro (MDA-MB-231 IC50=24.4 nM), and displays efficacious anti-tumor activity in vivo. |
| PC-36025 |
CCI-007
Apoptosis inducer
|
CCI-007 (CCI 007) is a selective inhibitor of MLL-r, CALM-AF10 and SET-NUP214 leukemia with IC50 of 3.5 uM against MLL-r leukemia cell line PER-485. |
| PC-63230 |
NSC 745887
|
NSC 745887 is a small molecule that effectively inhibits the proliferation of various cancers by trapping DNA-topoisomerase cleavage, shows anticancer effects against human GBM cells via suppressing DcR3-associated signaling pathways. |
| PC-62441 |
Carubicin
|
Carubicin (Carminomycin) is an apoptosis inducer that targets the Golgi complex, induces apoptosis in CCRCC cells by a mechanism independent of p53 or HIF2, and induces cleavage of the Golgi protein p115 and the translocation of its C-terminal fragment to the nucleus. |
| PC-45496 |
Apoptosis Activator 2
Apoptosis activator
|
Apoptosis Activator 2 is an apoptosis activator that strongly induces caspase-3 activation, PARP cleavage, and DNA fragmentation, leads to the destruction of cells (Apaf-1 dependent) with IC50 of 4 uM. |
