| Cat. No. |
Product Name |
Information |
| PC-62441 |
Carubicin
|
Carubicin (Carminomycin) is an apoptosis inducer that targets the Golgi complex, induces apoptosis in CCRCC cells by a mechanism independent of p53 or HIF2, and induces cleavage of the Golgi protein p115 and the translocation of its C-terminal fragment to the nucleus. |
| PC-62440 |
GUT-70
|
GUT-70 is a tricyclic coumarin derived from Calophyllum brasiliense, markedly reduces cell proliferation, viability through G1 cell cycle arrest and increases apoptosis. |
| PC-45496 |
Apoptosis Activator 2
Apoptosis activator
|
Apoptosis Activator 2 is an apoptosis activator that strongly induces caspase-3 activation, PARP cleavage, and DNA fragmentation, leads to the destruction of cells (Apaf-1 dependent) with IC50 of 4 uM. |
| PC-42276 |
JPH203
LAT1 inhibitor
|
Nanvuranlat (JPH203, KYT-0353) is a potent, selective L-type amino acid transporter 1 (LAT1, SLC7A5) inhibitor with IC50 of 60 nM (leucine uptake inhibition), but not LAT2. |
| PC-27107 |
Isoalantolactone
Apoptosis inducer
|
Isoalantolactone is a sesquiterpene lactone compound isolated from the roots of Inula helenium L., induces apoptosis in various cancer cell lines. |
| PC-27001 |
Necrosis inhibitor IM-17
Necrosis inhibitor
|
IM-17 is a specific oxidative stress-induced necrosis inhibitor, inhibits necrotic cell death induced by H2O2 with IC50 of 1.0 uM in HL-60 cells, does not inhibit apoptosis induced by various anticancer drugs or Fas ligand, or necroptosis. |
| PC-27000 |
IM-54
Necrosis inhibitor
|
IM-54 is a specific oxidative stress-induced necrosis inhibitor, inhibits necrotic cell death induced by H2O2 with IC50 of 0.25 uM in HL-60 cells, does not inhibit apoptosis induced by various anticancer drugs or Fas ligand, or necroptosis. |
| PC-22902 |
Darinaparsin
Apoptosis inducer
|
Darinaparsin (ZIO-101) is a novel arsenical apoptosis inducer, induces apoptosis and oxidative stress to a greater extent than As(2)O(3), within c-Jun NH(2)-terminal kinase-dependent. |
| PC-22100 |
VDX-111
|
VDX-111 (AMPI-109) is a selectively active agent against TNBC cell lines, inhibits proliferation and induces apoptosis of multiple TNBC subtype cell lines with IC50 of 100 nM. |
| PC-22058 |
UM4118
Copper ionophore, Cuproptosis inducer
|
UM4118 is a potent, specific, and nongenotoxic molecule that acts as a copper ionophore, initiates a mitochondrial-based noncanonical form of cell death known as cuproptosis (IC50=40 nM, OCI-AML5 cells), disrupts intracellular metal homeostasis. |
| PC-21768 |
Raptinal
Apoptosis inducer
|
Raptinal is a small molecule rapid apoptosis inducer, initiates intrinsic pathway caspase-dependent apoptosis in multiple cell lines, also inhibits the activity of caspase-activated Pannexin 1 (PANX1). |
| PC-43429 |
Silvestrol aglycone
|
Silvestrol is a potential anticancer rocaglate derivative from Aglaia foveolata, induces apoptosis in cancer cells through the mitochondrial/apoptosome pathway. |
