Nanvuranlat (JPH203, KYT-0353) | LAT1 inhibitor

Chemical Structure : JPH203

CAS No.: 1037592-40-7

JPH203 (Nanvuranlat, KYT-0353, KYT0353, JPH-203)

Catalog No.: PC-42276Not For Human Use, Lab Use Only.

Nanvuranlat (JPH203, KYT-0353) is a potent, selective L-type amino acid transporter 1 (LAT1, SLC7A5) inhibitor with IC50 of 60 nM (leucine uptake inhibition), but not LAT2.

Packing	Price	Stock
5 mg	$98	In stock
10 mg	$168	In stock
25 mg	$298	In stock
50 mg	$488	In stock
100 mg		Get quote

Get Quotation Now

* Please select Quantity before adding items.

or Bulk Inquiry

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Biological Activity

Nanvuranlat (JPH203, KYT-0353) is a potent, selective L-type amino acid transporter 1 (LAT1, SLC7A5) inhibitor with IC50 of 60 nM (leucine uptake inhibition), but not LAT2.
JPH203 inhibits cell growth in HT-29 cells with IC50 of 4.1 uM, also inhibits (14)C-leucine uptake in mouse renal proximal tubule cells expressing LAT1 and inhibits cell growth with IC50 of 0.14 and 16.4 uM, respectively.
JPH203 significant inhibits HT-29 tumor growth in vivo.

Physicochemical Properties

M.Wt	472.32066
Formula	C23H19Cl2N3O4
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	L-Tyrosine, O-[(5-amino-2-phenyl-7-benzoxazolyl)methyl]-3,5-dichloro-

References

1. Oda K, et al. Cancer Sci. 2010 Jan;101(1):173-9.

2. Yun DW, et al. J Pharmacol Sci. 2014;124(2):208-17.

3. Wempe MF, et al. Drug Metab Pharmacokinet. 2012;27(1):155-61.

4. Rosilio C, et al. Leukemia. 2015 Jun;29(6):1253-66.

JPH203 (Nanvuranlat, KYT-0353, KYT0353, JPH-203)

Biological Activity

Physicochemical Properties

References

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

Get Quote

* Indicates a Required FieldYour information is safe with us.