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JPH203

Chemical Structure : JPH203

CAS No.: 1037592-40-7

JPH203 (Nanvuranlat;KYT-0353;KYT0353;KYT 0353;JPH-203;JPH 203)

Catalog No.: PC-42276Not For Human Use, Lab Use Only.

Nanvuranlat (JPH203, KYT-0353) is a potent, selective L-type amino acid transporter 1 (LAT1, SLC7A5) inhibitor with IC50 of 60 nM (leucine uptake inhibition), but not LAT2.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Nanvuranlat (JPH203, KYT-0353) is a potent, selective L-type amino acid transporter 1 (LAT1, SLC7A5) inhibitor with IC50 of 60 nM (leucine uptake inhibition), but not LAT2.
JPH203 inhibits cell growth in HT-29 cells with IC50 of 4.1 uM, also inhibits (14)C-leucine uptake in mouse renal proximal tubule cells expressing LAT1 and inhibits cell growth with IC50 of 0.14 and 16.4 uM, respectively.
JPH203 significant inhibits HT-29 tumor growth in vivo.

Physicochemical Properties

M.Wt 472.32066
Formula C23H19Cl2N3O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

L-Tyrosine, O-[(5-amino-2-phenyl-7-benzoxazolyl)methyl]-3,5-dichloro-

References

1. Oda K, et al. Cancer Sci. 2010 Jan;101(1):173-9.

2. Yun DW, et al. J Pharmacol Sci. 2014;124(2):208-17.

3. Wempe MF, et al. Drug Metab Pharmacokinet. 2012;27(1):155-61.

4. Rosilio C, et al. Leukemia. 2015 Jun;29(6):1253-66.

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