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Chemical Structure : GUT-70
Catalog No.: PC-62440Not For Human Use, Lab Use Only.
GUT-70 is a tricyclic coumarin derived from Calophyllum brasiliense, markedly reduces cell proliferation, viability through G1 cell cycle arrest and increases apoptosis.
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GUT-70 is a tricyclic coumarin derived from Calophyllum brasiliense, markedly reduces cell proliferation, viability through G1 cell cycle arrest and increases apoptosis; shows binding affinity to heat-shock protein 90 (Hsp90) and ubiquitin-dependent proteasomal degradation of Hsp90 client proteins, including cyclin D1, Raf-1, Akt, and mt-p53; also inhibits HIV-1 replication in both acutely and chronically infected cells through suppression of NF-κB.
| M.Wt | 382.456 | |
| Formula | C23H26O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Kimura S, et al. Int J Cancer. 2005 Jan 1;113(1):158-65.
2. Jin L, et al. Br J Cancer. 2011 Jan 4;104(1):91-100.
3. Kudo E, et al. Bioorg Med Chem Lett. 2013 Feb 1;23(3):606-9.
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