Catalog No.: PC-22058Not For Human Use, Lab Use Only.
UM4118 is a potent, specific, and nongenotoxic molecule that acts as a copper ionophore, initiates a mitochondrial-based noncanonical form of cell death known as cuproptosis (IC50=40 nM, OCI-AML5 cells), disrupts intracellular metal homeostasis.
UM4118 is a potent, specific, and nongenotoxic molecule that acts as a copper ionophore, initiates a mitochondrial-based noncanonical form of cell death known as cuproptosis (IC50=40 nM, OCI-AML5 cells), disrupts intracellular metal homeostasis. UM4118 is able to complex metals, in particular copper and zinc. UM4118 acts as a copper ionophore which cytotoxicity relies on mitochondrial respiration UM4118 induces cell death by cuproptosis ABCB7 overexpression partially rescued UM4118-induced cell death in SF3B1-mutated cells.
Physicochemical Properties
M.Wt
248.29
Formula
C16H12N2O
Appearance
Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
N-(naphthalen-1-yl)picolinamide
References
1. Céline Moison, et al. Sci Adv. 2024 Mar 22;10(12):eadl4018.
