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Chemical Structure : UM4118
CAS No.: 75358-95-1
Catalog No.: PC-22058Not For Human Use, Lab Use Only.
UM4118 is a potent, specific, and nongenotoxic molecule that acts as a copper ionophore, initiates a mitochondrial-based noncanonical form of cell death known as cuproptosis (IC50=40 nM, OCI-AML5 cells), disrupts intracellular metal homeostasis.
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UM4118 is a potent, specific, and nongenotoxic molecule that acts as a copper ionophore, initiates a mitochondrial-based noncanonical form of cell death known as cuproptosis (IC50=40 nM, OCI-AML5 cells), disrupts intracellular metal homeostasis.
UM4118 is able to complex metals, in particular copper and zinc.
UM4118 acts as a copper ionophore which cytotoxicity relies on mitochondrial respiration
UM4118 induces cell death by cuproptosis
ABCB7 overexpression partially rescued UM4118-induced cell death in SF3B1-mutated cells.
| M.Wt | 248.29 | |
| Formula | C16H12N2O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N-(naphthalen-1-yl)picolinamide |
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1. Céline Moison, et al. Sci Adv. 2024 Mar 22;10(12):eadl4018.
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