Catalog No.: PC-22902Not For Human Use, Lab Use Only.
Darinaparsin (ZIO-101) is a novel arsenical apoptosis inducer, induces apoptosis and oxidative stress to a greater extent than As(2)O(3), within c-Jun NH(2)-terminal kinase-dependent.
Darinaparsin (ZIO-101) is a novel arsenical apoptosis inducer, induces apoptosis and oxidative stress to a greater extent than As(2)O(3), within c-Jun NH(2)-terminal kinase-dependent. Darinaparsin is significantly more potent than As(2)O(3) at mediating apoptosis in various malignant cell lines and is highly active against APL cells derived for As(2)O(3) resistance. Darinaparsin does not induce promyelocytic leukemia/retinoic acid receptor alpha (PML/RAR alpha) degradation or rearrange PML nuclear bodies in APL cells. Darinaparsin efficiently kills tumor cells with increased antioxidant capacity and drug exporters.
