Chemical Structure : Necrox-5 methanesulfonate
CAS No.:
1383718-29-3
Necrox-5 methanesulfonate
(Necrosis inhibitor 5)
Catalog No.: PC-62587Not For Human Use, Lab Use Only.
NecroX-5 is a novel necroptosis inhibitor that reduces mitochondrial oxidative stress, prevents hypoxia/reoxygenation injury by inhibiting the mitochondrial calcium uniporter.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
NecroX-5 is a novel necroptosis inhibitor that reduces mitochondrial oxidative stress, prevents hypoxia/reoxygenation injury by inhibiting the mitochondrial calcium uniporter; improves mitochondrial oxygen consumption, and suppresses mitochondrial Ca(2+) overload during reoxygenation in an in vitro rat heart HR model, reduces the ouabain- or histamine-induced increase in mitochondrial Ca(2+).
Physicochemical Properties
|
M.Wt
|
645.801
|
|
Formula
|
C27H39N3O9S3
|
|
Appearance
|
Solid
|
|
CAS No.
|
|
|
Storage
|
- Solide Powder
-
-20 °C 12 Months; 4°C 6 Months
|
- In Solvent
-
-80 °C 6 Months; -20°C 6 Months
|
|
Shipping
|
|
|
Solubility
|
10 mM in DMSO
|
|
Chemical Name/SMILES
|
5-[(1,1-dioxido-4-thiomorpholinyl)methyl]-2-phenyl-N-[(tetrahydro-2H-pyran-4-yl)methyl]-1H-indol-7-amine, dimethanesulfonate
|
References
1. Thu VT, et al. Cardiovasc Res. 2012 May 1;94(2):342-50.
2. Li X, et al. Allergy. 2016 Feb;71(2):198-209.
3. Park JH, et al. Int J Oncol. 2017 Jan;50(1):185-192.
4. Thu VT, et al. Korean J Physiol Pharmacol. 2016 Mar;20(2):201-11.
Contact Us
sales@probechem.com
