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Chemical Structure : Necrox-5 methanesulfonate
Catalog No.: PC-62587Not For Human Use, Lab Use Only.
NecroX-5 is a novel necroptosis inhibitor that reduces mitochondrial oxidative stress, prevents hypoxia/reoxygenation injury by inhibiting the mitochondrial calcium uniporter.
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NecroX-5 is a novel necroptosis inhibitor that reduces mitochondrial oxidative stress, prevents hypoxia/reoxygenation injury by inhibiting the mitochondrial calcium uniporter; improves mitochondrial oxygen consumption, and suppresses mitochondrial Ca(2+) overload during reoxygenation in an in vitro rat heart HR model, reduces the ouabain- or histamine-induced increase in mitochondrial Ca(2+).
| M.Wt | 645.801 | |
| Formula | C27H39N3O9S3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Thu VT, et al. Cardiovasc Res. 2012 May 1;94(2):342-50.
2. Li X, et al. Allergy. 2016 Feb;71(2):198-209.
3. Park JH, et al. Int J Oncol. 2017 Jan;50(1):185-192.
4. Thu VT, et al. Korean J Physiol Pharmacol. 2016 Mar;20(2):201-11.
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