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VDX-111

Chemical Structure : VDX-111

CAS No.: 158983-23-4

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VDX-111 (AMPI-109, VDX111)

Catalog No.: PC-22100Not For Human Use, Lab Use Only.

VDX-111 (AMPI-109) is a selectively active agent against TNBC cell lines, inhibits proliferation and induces apoptosis of multiple TNBC subtype cell lines with IC50 of 100 nM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

VDX-111 (AMPI-109) is a selectively active agent against TNBC cell lines, inhibits proliferation and induces apoptosis of multiple TNBC subtype cell lines with IC50 of 100 nM.
VDX-111 (AMPI-109) also inhibits the growth of a panel of ovarian cancer cell lines, focusing on BRCA wild-type lines.
VDX-111 (AMPI-109) causes a dose-dependent loss of cell viability across ovarian cancer cell lines.
VDX-111 (AMPI-109) inhibits tumor growth in patient-derived xenograft and syngeneic murine models.

Physicochemical Properties

M.Wt 537.57
Formula C29H45BrO4
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(1R,3S,5Z)-3-Hydroxy-4-methylene-5-[(2E)-2-[(1R,3aS,7aR)-octahydro-1-[(1R)-5-hydroxy-1,5-dimethylhexyl]-7a-methyl-4H-inden-4-ylidene]

References

1. Hamid H Gari, et al. Oncotarget. 2016 Mar 29;7(13):15757-71.

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