Chemical Structure : Silvestrol aglycone
CAS No.:
960365-65-5
Silvestrol aglycone
Catalog No.: PC-43429Not For Human Use, Lab Use Only.
Silvestrol is a potential anticancer rocaglate derivative from Aglaia foveolata, induces apoptosis in cancer cells through the mitochondrial/apoptosome pathway.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
Silvestrol is a potential anticancer rocaglate derivative from Aglaia foveolata, induces apoptosis in cancer cells through the mitochondrial/apoptosome pathway; effectively targets the cyclin/CDK/Rb pathway, and additionally induces cytotoxicity via intrinsic apoptosis, exhibits low nanomolar potency both in MCL cell lines and primary MCL tumor cells; demonstrates B-cell selective activity in chronic lymphocytic leukemia and acute lymphoblastic leukemia in vitro and in vivo.
Physicochemical Properties
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M.Wt
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Formula
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C27H26O8
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20 °C 12 Months; 4°C 6 Months
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- In Solvent
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-80 °C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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1H-Cyclopenta[b]benzofuran-2-carboxylic acid, 2,3,3a,8b-tetrahydro-1,6,8b-trihydroxy-8-methoxy-3a-(4-methoxyphenyl)-3-phenyl-, methyl ester, (1R,2R,3S,3aR,8bS)-
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References
1. Lucas DM, et al. Blood. 2009 May 7;113(19):4656-66.
2. Kim S, et al. Anticancer Res. 2007 Jul-Aug;27(4B):2175-83.
3. Hwang BY, et al. J Org Chem. 2004 May 14;69(10):3350-8.
4. Alinari L, et al. Clin Cancer Res. 2012 Sep 1;18(17):4600-11.
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