Imexon |CAS:59643-91-3 Probechem Biochemicals

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Chemical Structure : Imexon

Imexon (Amplimexon;BM 06002)

Catalog No.: PC-61309Not For Human Use, Lab Use Only.

A 2-cyanoaziridine derivative with antitumor activity in some types of cancer, including pancreatic, lung, breast, prostate, melanoma, and multiple myeloma.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

A 2-cyanoaziridine derivative with antitumor activity in some types of cancer, including pancreatic, lung, breast, prostate, melanoma, and multiple myeloma; induces mitochondrial oxidation and induces apoptosis via a pathway involving cleaved caspase-3, caspase-9, and/or caspase-8; an apoptosis inducer agent.

Blood Cancer

Phase 2 Clinical

Physicochemical Properties

M.Wt	111.104
Formula	C4H5N3O
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-Amino-1,3-diazabicyclo[3.1.0]hex-3-en-2-one

References

1. Ziegler AE, et al. Exp Pathol (Jena). 1977;14(6):321-7.

2. Hersh EM, et al. J Natl Cancer Inst. 1992 Aug 19;84(16):1238-44.

3. Baker AF, et al. Clin Cancer Res. 2007 Jun 1;13(11):3388-94.

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Imexon (Amplimexon;BM 06002)

Biological Activity

Physicochemical Properties

References

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