Catalog No.: PC-21768Not For Human Use, Lab Use Only.
Raptinal is a small molecule rapid apoptosis inducer, initiates intrinsic pathway caspase-dependent apoptosis in multiple cell lines, also inhibits the activity of caspase-activated Pannexin 1 (PANX1).
Raptinal is a small molecule rapid apoptosis inducer, initiates intrinsic pathway caspase-dependent apoptosis in multiple cell lines, also inhibits the activity of caspase-activated Pannexin 1 (PANX1). Raptinal rapidly trigger apoptosis by promoting the release of cytochrome c from the mitochondria and subsequently activating the intrinsic apoptotic pathway. Raptinal is very effective at inducing apoptosis in a variety of different cell types in vitro and in vivo. Raptinal inhibits cleavage-activated PANX1 via a mechanism distinct to other well-described PANX1 inhibitors such as carbenoxolone and trovafloxacin. Raptinal also interferes with PANX1-regulated apoptotic processes including the release of the 'find-me' signal ATP, the formation of apoptotic cell-derived extracellular vesicles, as well as NLRP3 inflammasome activation. Raptinal is the first compound that can simultaneously induce apoptosis and inhibit PANX1 channels.
Physicochemical Properties
M.Wt
386.45
Formula
C28H18O2
Appearance
Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
9H,9'H-[9,9'-Bifluorene]-9,9'-dicarbaldehyde
References
1. Palchaudhuri R, et al. Cell Rep. 2015 Dec 1;13(9):2027-36.
2. Heimer S, et al. Cell Death Dis. 2019 Jul 19;10(8):556.
3. Santavanond JP, et al. Cell Death Dis. 2024 Feb 9;15(2):123.
