Chemical Structure : Flavokawain B
CAS No.:
1775-97-9
Flavokawain B
Catalog No.: PC-35324Not For Human Use, Lab Use Only.
Flavokawain B is a natural chalcone that can induce apoptosis in androgen receptor-negative, hormone-refractory prostate cancer cell lines (IC50=3-50 uM), via up-regulation of death-receptor 5 and Bim expression.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
Flavokawain B is a natural chalcone that can induce apoptosis in androgen receptor-negative, hormone-refractory prostate cancer cell lines (IC50=3-50 uM), via up-regulation of death-receptor 5 and Bim expression; induces apoptosis in human myeloid leukemic cells by modifying NF-κB, possesses potential anti-inflammation and anti-cancer activities; also exhibits significant inhibition of the neurogenic nociceptive induced by intraplantar injections of glutamate and capsaicin in mice.
Physicochemical Properties
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M.Wt
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284.311
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Formula
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C17H16O4
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20 °C 12 Months; 4°C 6 Months
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- In Solvent
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-80 °C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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2-Propen-1-one, 1-(2-hydroxy-4,6-dimethoxyphenyl)-3-phenyl-, (E)-
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References
1. Tang Y, et al. Int J Cancer. 2010 Oct 15;127(8):1758-68.
2. Lee JJ, et al. Anticancer Res. 2018 May;38(5):2771-2778.
3. Mohamad AS, et al. Eur J Pharmacol. 2010 Nov 25;647(1-3):103-9.
4. Abu N, et al. Nat Prod Commun. 2015 Jul;10(7):1199-202.
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