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WZY-321

Chemical Structure : WZY-321

CAS No.: 2158199-62-1

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WZY-321 (WZY321)

Catalog No.: PC-38741Not For Human Use, Lab Use Only.

WZY-321 a small molecule glioma cell apoptosis inducer, binds to XAF1 3-UTR and decreases XAF1 (X-linked inhibitor of apoptosis-associated factor 1) mRNA levels.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    WZY-321 a small molecule glioma cell apoptosis inducer, binds to XAF1 3-UTR and decreases XAF1 (X-linked inhibitor of apoptosis-associated factor 1) mRNA levels.
    WZY-321 increased XAF1 expression in glioma cells, and up-regulated XAF1 resulted in glioma cell apoptosis.
    WZY-321 also decreased miR-873 expression and increased lncRNA MTM expression in glioma cells, and down-regulated miR-873 or up-regulated MTM lead to glioma cell apoptosis.

    Physicochemical Properties

    M.Wt 341.747
    Formula C18H12ClNO4
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    3-chloro-10-hydroxy-8,13b-dihydro-5H,7H-benzo[e]benzofuro[2',3':3,4]pyrido[2,1-b][1,3]oxazin-5-one

    References

    1. Guan Sun, et al. J Cancer. 2022 Apr 18;13(7):2312-2321.

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