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Chemical Structure : Devimistat
CAS No.: 95809-78-2
Catalog No.: PC-38723Not For Human Use, Lab Use Only.
CPI-613 (Devimistat) is an antimitochondrial metabolism agent that specifically induces inactivating phosphorylation of tumor cell PDH via stimulation of PDKs 1 to 4, inhibits KGDH function strongly and rapidly, selectively in tumor cells.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $128 | In stock | |
| 50 mg | $198 | In stock | |
| 100 mg | $328 | In stock | |
| 1 g | Get quote |
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CPI-613 (Devimistat) is an antimitochondrial metabolism agent that specifically induces inactivating phosphorylation of tumor cell PDH via stimulation of PDKs 1 to 4, inhibits KGDH function strongly and rapidly, selectively in tumor cells.
CPI-613 down-regulated the expression of Cyclin D3, E1, E2, F, A2, B1 and CDK2 genes of BxPC-3 pancreatic cancer cells but not non-transformed NIH-3T3 mouse fibroblast cells.
CPI-613 induced a correspondingly rapid, powerful redox signal in tumor cell mitochondria.
CPI-613 demonstrated tumor growth inhibition in human xenograft mouse models.
| M.Wt | 388.584 | |
| Formula | C22H28O2S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
6,8-bis[(phenylmethyl)thio]-octanoic acid |
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1. Stuart SD, et al. Cancer Metab. 2014 Mar 10;2(1):4.
2. Pardee TS, et al. Clin Cancer Res. 2014 Oct 15;20(20):5255-64.
3. Lee KC, et al. Ann Transl Med. 2014 Sep;2(9):91.
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