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Chemical Structure : NecroX-7
CAS No.: 1120333-38-1
Catalog No.: PC-62586Not For Human Use, Lab Use Only.
NecroX-7 is a small molecule necrosis modulator and potent antioxidant molecule, which can be bound to some types of radicals and especially NAPQI.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $188 | In stock | |
| 25 mg | $298 | In stock | |
| 50 mg | $498 | In stock | |
| 100 mg | Get quote |
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NecroX-7 is a small molecule necrosis modulator and potent antioxidant molecule, which can be bound to some types of radicals and especially NAPQI.
NecroX-7 inhibits osteoclast differentiation by suppressing NF-κB activity and c-Fos expression, reduces hepatic necrosis secondary to IR injury in vivo.
NecroX-7 decreases t-BHP- and APAP-induced cell death and ROS/RNS formation in HepG2 human hepatocarcinoma and primary mouse hepatocytes.
NecroX-7 also protects mice from APAP-induced liver injury and lethality by binding directly to NAPQI.
| M.Wt | 439.574 | |
| Formula | C24H29N3O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
4-((7-((1-(methylsulfonyl)piperidin-4-yl)amino)-2-phenyl-1H-indol-5-yl)methyl)thiomorpholine 1,1-dioxide |
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1. Choi JM, et al. Transplant Proc. 2010 Nov;42(9):3414-21.
2. Grootaert MO, et al. Atherosclerosis. 2016 Sep;252:166-74.
3. Lee DW, et al. Am J Physiol Heart Circ Physiol. 2011 Sep;301(3):H1004-14.
4. Park JH, et al. Antioxid Redox Signal. 2013 May 10;18(14):1713-22.
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