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Necrox-7

Chemical Structure : Necrox-7

CAS No.: 1120332-55-9

Necrox-7 (NecX, NecroX 7)

Catalog No.: PC-22708Not For Human Use, Lab Use Only.

NecroX-7 (NecX, NecroX 7) is a small molecule necrosis inhibitor by inhibiting high-mobility group box 1 protein (HMGB1) release.

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5 mg $128 In stock
10 mg $198 In stock
25 mg $358 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

NecroX-7 (NecX, NecroX 7) is a small molecule necrosis inhibitor by inhibiting high-mobility group box 1 protein (HMGB1) release.
NecroX-7 attenuated the hepatocyte lethality caused by hepatic IR injury in a large animal setting.
NecroX-7 inhibited the HMGB1-induced release of tumor necrosis factor-alpha (TNF-α), interleukin (IL)-1β, and macrophage inflammatory protein (MIP)-1β, as well as the expression of p53-upregulated modulator of apoptosis (PUMA) and the excessive inflammatory microenvironment, including nuclear factor-kB (NF-kB) pathways.
NecroX-7 reduces necrotic core formation in atherosclerotic plaques of Apoe knockout mice.

Physicochemical Properties

M.Wt 439.57
Formula C24H29N3O3S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

4-((2-Phenyl-7-((tetrahydro-2H-pyran-4-yl)amino)-1H-indol-5-yl)methyl)thiomorpholine 1,1-dioxide

References

1. Park J, et al. Toxicol Appl Pharmacol. 2012 Aug 15;263(1):1-6.

2. Kim HJ, et al. Life Sci. 2012 Nov 2;91(19-20):928-34.

3. Im KI, et al. Mucosal Immunol. 2019 Sep;12(5):1070-1081.

4. Lee JH, et al. Transplant Proc. 2016 Dec;48(10):3406-3414.

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