Chemical Structure : Necrox-7
CAS No.: 1120332-55-9
Catalog No.: PC-22708Not For Human Use, Lab Use Only.
NecroX-7 (NecX, NecroX 7) is a small molecule necrosis inhibitor by inhibiting high-mobility group box 1 protein (HMGB1) release.
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10 mg | $198 | In stock | |
25 mg | $358 | In stock | |
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NecroX-7 (NecX, NecroX 7) is a small molecule necrosis inhibitor by inhibiting high-mobility group box 1 protein (HMGB1) release.
NecroX-7 attenuated the hepatocyte lethality caused by hepatic IR injury in a large animal setting.
NecroX-7 inhibited the HMGB1-induced release of tumor necrosis factor-alpha (TNF-α), interleukin (IL)-1β, and macrophage inflammatory protein (MIP)-1β, as well as the expression of p53-upregulated modulator of apoptosis (PUMA) and the excessive inflammatory microenvironment, including nuclear factor-kB (NF-kB) pathways.
NecroX-7 reduces necrotic core formation in atherosclerotic plaques of Apoe knockout mice.
M.Wt | 439.57 | |
Formula | C24H29N3O3S | |
Appearance | Solid | |
Storage |
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Solubility |
10 mM in DMSO |
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Chemical Name/SMILES |
4-((2-Phenyl-7-((tetrahydro-2H-pyran-4-yl)amino)-1H-indol-5-yl)methyl)thiomorpholine 1,1-dioxide |
1. Park J, et al. Toxicol Appl Pharmacol. 2012 Aug 15;263(1):1-6.
2. Kim HJ, et al. Life Sci. 2012 Nov 2;91(19-20):928-34.
3. Im KI, et al. Mucosal Immunol. 2019 Sep;12(5):1070-1081.
4. Lee JH, et al. Transplant Proc. 2016 Dec;48(10):3406-3414.
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