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Apoxidole-1

Chemical Structure : Apoxidole-1

CAS No.: 3027990-81-1

Apoxidole-1 (Apoxidole 1)

Catalog No.: PC-20021Not For Human Use, Lab Use Only.

Apoxidole-1 is a potent, selective type IV inhibitor of indoleamine 2,3-dioxygenase 1 (IDO1), Apoxidole-1 reduces cellular kynurenine (Kyn) levels with IC50 of 46.7 in HeLa cells, but does not inhibit IDO1 expression.

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    Biological Activity

    Apoxidole-1 is a potent, selective type IV inhibitor of indoleamine 2,3-dioxygenase 1 (IDO1), Apoxidole-1 reduces cellular kynurenine (Kyn) levels with IC50 of 46.7 in HeLa cells, but does not inhibit IDO1 expression.
    Apoxidole-1 targets apo-IDO1 and interferes with heme binding, induces unique amino acid positioning as revealed by crystal structure analysis.
    Apoxidole-1 does not inhibit TDO or IDO2.
    Apoxidole-1 directly binds to IDO1 with an apparent dissociation constant (KD,app) of 1.1 uM, ITC KD of 20.7 nM.
    Apoxidole-1 is inactive in the IDO1 enzymatic assay at 25°C, after preincubation at 37°C Apoxidole-1 dose-dependently decreases IDO1 activity.

    Physicochemical Properties

    M.Wt 596.70
    Formula C31H36N2O8S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    2,3,6-Pyridinetricarboxylic acid, 1,2,5,6-tetrahydro-6-(1-methyl-1H-indol-2-yl)-1-[(4-methylphenyl)sulfonyl]-, 2-(1,1-dimethylethyl) 3-ethyl 6-methyl ester, (2S,6R)-

    References

    1. Caitlin Davies, et al. Angew Chem Int Ed Engl. 2022 Oct 4;61(40):e202209374.

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