Catalog No.: PC-38253Not For Human Use, Lab Use Only.
Aprotinin is a single chain polypeptide isolated from bovine lung with antifibrinolytic and anti-inflammatory activities, inhibits trypsin and chymotrypsin with Ki of 0.06 pM and 9 nM respectively.
Aprotinin is a single chain polypeptide isolated from bovine lung with antifibrinolytic and anti-inflammatory activities, inhibits trypsin and chymotrypsin with Ki of 0.06 pM and 9 nM respectively.
As a broad-spectrum serine protease inhibitor, aprotinin bovine competitively and reversibly inhibits the activity of a number of different esterases and proteases, including trypsin, chymotrypsin, kallikrein, plasmin, tissue plasminogen activator, and tissue and leukocytic proteinases, resulting in attenuation of the systemic inflammatory response (SIR), fibrinolysis, and thrombin generation.
Aprotinin also inhibits pro-inflammatory cytokine release and maintains glycoprotein homeostasis.
