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Arbemnifosbuvir

Chemical Structure : Arbemnifosbuvir

CAS No.: 1998705-63-7

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Arbemnifosbuvir (AT-752, AT752)

Catalog No.: PC-21967Not For Human Use, Lab Use Only.

Arbemnifosbuvir (AT-752)  a double prodrug of a guanosine nucleotide analog with activity against dengue virus (DENV), potently inhibits DENV1-4 with EC50 of 0.5 uM in Huh-7 cells, inhibits NS5 active site of all four DENV1-4 NS5 RdRps.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Arbemnifosbuvir (AT-752)  a double prodrug of a guanosine nucleotide analog with activity against dengue virus (DENV), potently inhibits DENV1-4 with EC50 of 0.5 uM in Huh-7 cells, inhibits NS5 active site of all four DENV1-4 NS5 RdRps.

Physicochemical Properties

M.Wt 581.54
Formula C24H33FN7O7P
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

isopropyl ((R)-(((2R,3R,4R,5R)-5-(2-amino-6-(methylamino)-9H-purin-9-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)-L-alaninate

References

1. Lin K, et al. PLoS Negl Trop Dis. 2022 Jan 24;16(1):e0009937.

2. Feracci M, et al. Antiviral Res. 2023 Apr;212:105574.

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