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Arbemnifosbuvir

Chemical Structure : Arbemnifosbuvir

CAS No.: 1998705-63-7

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Arbemnifosbuvir (AT-752, AT752)

Catalog No.: PC-21967Not For Human Use, Lab Use Only.

Arbemnifosbuvir (AT-752) is a double prodrug of a guanosine nucleotide analog with activity against dengue virus (DENV), potently inhibits DENV1-4 with EC50 of 0.5 uM in Huh-7 cells, inhibits NS5 active site of all four DENV1-4 NS5 RdRps.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    Arbemnifosbuvir (AT-752) is a double prodrug of a guanosine nucleotide analog with activity against dengue virus (DENV), potently inhibits DENV1-4 with EC50 of 0.5 uM in Huh-7 cells, inhibits NS5 active site of all four DENV1-4 NS5 RdRps.

    Physicochemical Properties

    M.Wt 581.54
    Formula C24H33FN7O7P
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    isopropyl ((R)-(((2R,3R,4R,5R)-5-(2-amino-6-(methylamino)-9H-purin-9-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)-L-alaninate

    References

    1. Lin K, et al. PLoS Negl Trop Dis. 2022 Jan 24;16(1):e0009937.

    2. Feracci M, et al. Antiviral Res. 2023 Apr;212:105574.

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