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Arimoclomol

Chemical Structure : Arimoclomol

CAS No.: 289893-25-0

Arimoclomol (BRX-220, BRX 220, BRX220)

Catalog No.: PC-60544Not For Human Use, Lab Use Only.

Arimoclomol (BRX-220) is a nontoxic heat shock protein (HSP) coinducer and potentiator of the heat shock response.

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5 mg $88 In stock
10 mg $128 In stock
25 mg $218 In stock
50 mg $358 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Arimoclomol (BRX-220) is a nontoxic heat shock protein (HSP) coinducer and potentiator of the heat shock response.
Arimoclomol (BRX-220) significantly increases pancreatic levels of HSP60 and HSP72 in vivo, significantly delays disease progression and prevents protein aggregation in the SOD1 mouse model of ALS.

Physicochemical Properties

M.Wt 313.782
Formula C14H20ClN3O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(R,Z)-3-(chloro((2-hydroxy-3-(piperidin-1-yl)propoxy)imino)methyl)pyridine 1-oxide

References

1. Kieran D, et al. Nat Med. 2004 Apr;10(4):402-5.

2. Parfitt DA, et al. Cell Death Dis. 2014 May 22;5:e1236.

3. Rakonczay Z Jr, et al. Free Radic Biol Med. 2002 Jun 15;32(12):1283-92.

4. Kalmar B, et al. J Neurochem. 2008 Oct;107(2):339-50.

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