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Arimoclomol maleate

Chemical Structure : Arimoclomol maleate

CAS No.: 289893-26-1

Arimoclomol maleate (BRX-220, BRX220)

Catalog No.: PC-60545Not For Human Use, Lab Use Only.

Arimoclomol maleate (BRX-220) is a nontoxic, orally active heat shock protein (HSP) coinducer and potentiator of the heat shock response.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Arimoclomol maleate (BRX-220) is a nontoxic, orally active heat shock protein (HSP) coinducer and potentiator of the heat shock response.
Arimoclomol maleate (BRX-220) significantly increases pancreatic levels of HSP60 and HSP72 in vivo, significantly delays disease progression and prevents protein aggregation in the SOD1 mouse model of ALS.

Physicochemical Properties

M.Wt 429.854
Formula C18H24ClN3O7
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

3-Pyridinecarboximidoyl chloride, N-[(2R)-2-hydroxy-3-(1-piperidinyl)propoxy]-, 1-oxide, (2Z)-2-butenedioate (1:1) (salt) (9CI)

References

1. Kieran D, et al. Nat Med. 2004 Apr;10(4):402-5.

2. Parfitt DA, et al. Cell Death Dis. 2014 May 22;5:e1236.

3. Rakonczay Z Jr, et al. Free Radic Biol Med. 2002 Jun 15;32(12):1283-92.

4. Kalmar B, et al. J Neurochem. 2008 Oct;107(2):339-50.

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