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Artefenomel

Chemical Structure : Artefenomel

CAS No.: 1029939-86-3

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Artefenomel (OZ439)

Catalog No.: PC-62987Not For Human Use, Lab Use Only.

Artefenomel (OZ439) is a novel, next-generation antimalarial ozonide that demonstrates high potentcy against P. falciparum in vitro and P. berghei in vivo (K1/NF54, IC50=2.0/3.2 nM).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    Artefenomel (OZ439) is a novel, next-generation antimalarial ozonide that demonstrates high potentcy against P. falciparum in vitro and P. berghei in vivo (K1/NF54, IC50=2.0/3.2 nM).

    Physicochemical Properties

    M.Wt 469.622
    Formula C28H39NO5
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    4-[2-(4-cis-Dispiro[cyclohexane-1,3'-[1,2,4]trioxolane-5',2''-tricyclo[3.3.1.13,7]decan]-4-ylphenoxy)ethyl]morpholine

    References

    1. Dong Y, et al. J Med Chem. 2017 Apr 13;60(7):2654-2668.

    2. Kim HS, et al. J Med Chem. 2017 Apr 13;60(7):2651-2653.

    3. Macintyre F, et al. BMC Med. 2017 Oct 9;15(1):181.

    4. Yang T, et al. Antimicrob Agents Chemother. 2016 Jul 22;60(8):4501-10.

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