Catalog No.: PC-27146Not For Human Use, Lab Use Only.
Artesunate is an antimalarial and potent, hematin-dependent inhibitor of P. falciparum exported protein 1 (EXP1, PfMGST) with IC50 of 2.05 nM, inhibits EXP1 glutathione transferase activity toward hematin, also is a potential inhibitor of STAT-3.
Artesunate is an antimalarial and potent, hematin-dependent inhibitor of P. falciparum exported protein 1 (EXP1, PfMGST) with IC50 of 2.05 nM, inhibits EXP1 glutathione transferase activity toward hematin, also is a potential inhibitor of STAT-3. Artesunate directly targets glucosylceramidase to suppress hepatocellular carcinoma proliferation and trigger apoptosis. Artesunate inhibits IL-6 driven STAT-3-DNA binding activity with comparable potency to S3I-201 in a cell free system. Artesunate interferes with STAT-3 dimerization and suppression of both constitutive and IL-6 inducible STAT-3 in vitro. Artesunate also exhibitsselective cytotoxicity of cancer cells over normal cells in vitro.
