Arvenin I | MKK3 activator | Probechem Biochemicals

Chemical Structure : Arvenin I

CAS No.: 65247-27-0

Arvenin I (Cucurbitacin B 2-O-β-d-glucoside)

Catalog No.: PC-27189Not For Human Use, Lab Use Only.

Arvenin I is a plant natural product that activates T cells within the cancer-competitive environment, covalently reacts with and hyperactivates MKK3 (Mitogen-activated protein kinase kinase 3, MAP2K3), thereby reviving the mitochondrial fitness of exhausted T cells through the activation of p38MAPK pathway.

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Biological Activity

Physicochemical Properties

M.Wt	720.85
Formula	C38H56O13
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R,E)-6-hydroxy-6-((2S,8S,9R,10R,13R,14S,16R,17R)-16-hydroxy-4,4,9,13,14-pentamethyl-3,11-dioxo-2-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2-methyl-5-oxohept-3-en-2-yl acetate

References

1. Takemoto M, et al. J Am Chem Soc. 2025 Jan 22;147(3):2902-2912.

2. Mata R, et al. J Nat Prod. 1988 Sep-Oct;51(5):836-9.

3. Singh VP, et al. Acc Chem Res. 2026 Jun 24. doi: 10.1021/acs.accounts.6c00316.

Arvenin I (Cucurbitacin B 2-O-β-d-glucoside)

Biological Activity

Physicochemical Properties

References

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