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Chemical Structure : Aster inhibitor AI-3d
Catalog No.: PC-21334Not For Human Use, Lab Use Only.
Aster inhibitor AI-3d is a potent, selective small molecule inhibitor of Aster proteins (encoded by the Gramd1a-c genes) with IC50 of 0.11 μM, 0.06 μM and 0.71 uM for Aster-A, Aster-B, and Aster-C, respectively.
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Aster inhibitor AI-3d is a potent, selective small molecule inhibitor of Aster proteins (encoded by the Gramd1a-c genes) with IC50 of 0.11 μM, 0.06 μM and 0.71 uM for Aster-A, Aster-B, and Aster-C, respectively.
AI-3d (10 uM) blocks cholesterol transfer by Asters, does not cause lysosomal cholesterol accumulation and not inhibit SREBP2 processing.
AI-3d is an Aster-selective inhibitor that blocks nonvesicular plasma membrane (PM) to endoplasmic reticulum (ER) cholesterol transport.
AI-3d inhibits both human and murine Asters. reduces intestinal cholesterol uptake.
AI-3d increased SREBP-2 target gene expression in human enteroids and differentiated Caco-2 cells, reduces dietary cholesterol absorption into the circulation in vivo.
| M.Wt | 429.69 | |
| Formula | C28H47NO2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Xu Xiao, et al. Proc. Natl. Acad. Sci. U.S.A. 118, e2024149118 (2021).
2. Ferrari A, et al. Science. 2023 Nov 10;382(6671):eadf0966.
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