Catalog No.: PC-60507Not For Human Use, Lab Use Only.
Atabecestat (JNJ-54861911) is a potent, selective, brain penetrable and orally bioavailable BACE1 inhibitor with IC50 of 9.8 nM in HTRF assays, inhibits BACE2 (IC50=5.6 nM) with comparable potency as for BACE1.
Atabecestat (JNJ-54861911) is a potent, selective, brain penetrable and orally bioavailable BACE1 inhibitor with IC50 of 9.8 nM in HTRF assays, inhibits BACE2 (IC50=5.6 nM) with comparable potency as for BACE1.
Atabecestat (JNJ-54861911) pontently inhibits levels of secreted Aβ40 in human APP-transfected human neuroblastoma (SH-SY5Y) cells with IC50 of 1.1 nM.
Atabecestat (JNJ-54861911) shows comparable potency for mouse and dog BACE1 with IC50 values of 9.7 and 12 nM, respectively.
Atabecestat (JNJ-54861911) is extremely selective over CatD and CatE (IC50 = >100 μM).
Atabecestat (JNJ-54861911) demonstrated robust and dose-dependent Aβ reduction and showed sufficient safety margins in preclinical models.
