Ataluren (PTC-124, PTC124)

Chemical Structure : Ataluren

CAS No.: 775304-57-9

Catalog No.: PC-21295Not For Human Use, Lab Use Only.

Ataluren (PTC-124, PTC124) is an orally bioavailable small molecule that selectively induces ribosomal readthrough of premature but not normal termination codons.

Packing	Price	Stock
25 mg	$58	In stock
100 mg	$98	In stock
250 mg	$148	In stock
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Biological Activity

Ataluren (PTC-124, PTC124) is an orally bioavailable small molecule that selectively induces ribosomal readthrough of premature but not normal termination codons.
PTC124 (Ataluren) promotes suppression of the human CFTR-G542X nonsense allele in cystic fibrosis (CF) mouse model.
PTC124 (Ataluren) is a potent firefly luciferase (FLuc) inhibitor with IC50 of 7 nM.
PTC124 (Ataluren) promotes ribosomal readthrough of premature stop codons in mRNA and offers therapeutic potential for multiple genetic diseases.

Physicochemical Properties

M.Wt	284.25
Formula	C15H9FN2O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(5-(2-Fluorophenyl)-1,2,4-oxadiazol-3-yl)benzoic acid

References

1. Auld DS, et al. Proc Natl Acad Sci U S A. 2009 Mar 3;106(9):3585-90.

2. Du M, et al. Proc Natl Acad Sci U S A. 2008 Feb 12;105(6):2064-9.

3. Welch EM, et al. Nature. 2007 May 3;447(7140):87-91.